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Article

Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.

Molecular psychiatry - 1 Dec 2021

Lim Chae-Seok, Kim Min Jung, Choi Ja Eun, Islam Md Ariful, Lee You-Kyung, Xiong Yinyi, Shim Kyu-Won, Yang Jung-Eun, Lee Ro Un, Lee Jiah, Park Pojeong, Kwak Ji-Hye, Seo Hyunhyo, Kim Chul Hoon, Lee Jae-Hyung, Lee Yong-Seok, Hwang Su-Kyeong, Lee Kyungmin, Lee Jin-A, Kaang Bong-Kiun

Abstract excerpt

Heterogeneity in the etiopathology of autism spectrum disorders (ASD) limits the development of generic remedies, requires individualistic and patient-specific research. Recent progress in human-induced pluripotent stem cell (iPSC) technology provides a novel platform for modeling ASDs for studying complex neuronal phenotypes. In this study, we generated telencephalic induced neuronal (iN) cells from iPSCs...

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Source

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Identifiers

PMID: 34253863
DOI: 10.1038/s41380-021-01216-9
PMCID: PMC8873012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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