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Article

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene<i>Dyrk1a</i>

22 Jan 2014

Abstract excerpt

The gene Dyrk1a is the mammalian ortholog of Drosophila minibrain. Dyrk1a localizes in the Down syndrome (DS) critical region of chromosome 21q22.2 and is a major candidate for the behavioral and neuronal abnormalities associated with DS. PFC malfunctions are a common denominator in several neuropsychiatric diseases, including DS, but the contribution of DYRK1A in PFC dysfunctions, in particular the synaptic...

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PMID: 24453307
DOI: 10.1523/jneurosci.2852-13.2014

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