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Article

NMDA receptor dysfunction in autism spectrum disorders.

Current opinion in pharmacology - 1 Feb 2015

Lee Eun-Jae, Choi Su Yeon, Kim Eunjoon

Abstract excerpt

Abnormalities and imbalances in neuronal excitatory and inhibitory synapses have been implicated in diverse neuropsychiatric disorders including autism spectrum disorders (ASDs). Increasing evidence indicates that dysfunction of NMDA receptors (NMDARs) at excitatory synapses is associated with ASDs. In support of this, human ASD-associated genetic variations are found in genes encoding NMDAR subunits....

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PMID: 25636159
DOI: 10.1016/j.coph.2014.10.007

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