Article

Cognitive behavioral phenotyping of <i>DSCAM</i> heterozygosity as a model for autism spectrum disorder

2024-06-03

Abstract excerpt

It is estimated that 1 in 36 children are affected by autism spectrum disorder (ASD) in the United States, which is nearly a twofold increase from a decade ago. Recent genetic studies have identified de novo loss-of-function (dnLoF) mutations in the Down Syndrome Cell Adhesion Molecule (DSCAM) as a strong risk factor for ASD. Previous research has shown that DSCAM ablation confers social interaction deficits an...

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Literature Corpus work: cb0f5b7f-3bf7-5dc1-9149-cb929f881276
DOI: 10.1101/2024.06.03.597158

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