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Article

Sex Steroids and Osteoarthritis: A Mendelian Randomization Study.

Frontiers in endocrinology - 1 Jan 2021

Yan Yi-Shang, Qu Zihao, Yu Dan-Qing, Wang Wei, Yan Shigui, Huang He-Feng

Abstract excerpt

Objective: Sex steroids are thought to contribute to the pathogenesis of osteoarthritis (OA). This study investigated the causal role of sex steroids in site- and sex-specific OA and risk of joint replacement surgery using the Mendelian randomization (MR) method. Methods: Instrumental variables for estradiol, dehydroepiandrosterone sulfate, testosterone (T), and dihydrotestosterone (DHT) were selected. We used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34248845
DOI: 10.3389/fendo.2021.683226
PMCID: PMC8261132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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