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Potential Benefits of Statin Therapy in Reducing Osteoarthritis Risk: A Mendelian Randomization Study.

Arthritis care & research - 1 Sept 2024

Zhang Lili, Sui Laijian, Li Jing, Zhang Rui, Pan Weimin, Lv Teng

Abstract excerpt

OBJECTIVE: The purpose of this study was to determine the causal effect of statins on osteoarthritis (OA) risk using Mendelian randomization (MR). METHODS: Single nucleotide polymorphism-based genome-wide association analyses of statins were collected from the UK Biobank and FinnGen dataset, and OA data were collected from the UK Biobank and Arthritis Research UK Osteoarthritis Genetics (arcOGEN) study....

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hydroxymethylglutaryl CoA Reductases
Mendelian Randomization Analysis
Osteoarthritis
Osteoarthritis, Hip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoarthritis, Knee

Protective Factors

Rosuvastatin Calcium

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PMID: 38570925
DOI: 10.1002/acr.25343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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