Using genetic instruments to estimate the causal effect of hormonal reproductive factors on osteoarthritis.

doi:10.3389/fpubh.2022.941067

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Article

Using genetic instruments to estimate the causal effect of hormonal reproductive factors on osteoarthritis.

Frontiers in public health - 1 Jan 2022

Wang Bingran, Wu Junhua, Li Han, Jin Xiaoyan, Sui Cong, Yu Zhen

Abstract excerpt

Objectives: Hormonal reproductive factors have been considered to play an important role in the etiology of osteoarthritis (OA). We performed Mendelian randomization (MR) to examine whether a causal effect existed between them. Methods: MR was performed by using publicly released genome-wide association study (GWAS) summary statistics to estimate the causal associations of three relevant exposures, including age...

Topics

Female
Humans
Genome-Wide Association Study
Osteoarthritis
Polymorphism, Single Nucleotide

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PMID: 36452961
DOI: 10.3389/fpubh.2022.941067
PMCID: PMC9702564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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