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Article

Osteoarthritis and cardiovascular disease: A Mendelian randomization study

18 Nov 2022

Abstract excerpt

Objective This Mendelian randomization (MR) study aimed to investigate the causal relationship between osteoarthritis (OA) and cardiovascular disease (CVD). Methods From a genome-wide association study of European ancestry, we selected single nucleotide polymorphisms for two types of OA, knee osteoarthritis (KOA) and hip osteoarthritis (HOA), as instrumental variables. We evaluated three types of CVD: coronary...

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PMID: 36465459
DOI: 10.3389/fcvm.2022.1025063

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