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Article

Causal association of menstrual reproductive factors on the risk of osteoarthritis: A univariate and multivariate Mendelian randomization study.

PloS one - 1 Jan 2024

Tan Xinzhe, Mei Yifang, Zhou Yihao, Liao Zhichao, Zhang Pengqi, Liu Yichang, Han Yixiao, Wang Dongyan

Abstract excerpt

OBJECTIVE: Several observational studies have revealed a potential relationship between menstrual reproductive factors (MRF) and osteoarthritis (OA). However, the precise causal relationship remains elusive. This study performed Mendelian randomization (MR) to provide deeper insights into this relationship. METHODS: Utilizing summary statistics of genome-wide association studies (GWAS), we conducted univariate MR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39213290
DOI: 10.1371/journal.pone.0307958
PMCID: PMC11364240

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