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Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives

30 Jan 2025

Abstract excerpt

Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations leads to a high rate of resistance to current therapies or reduces the efficacy of hematopoietic stem cell...

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PMID: 39885388
DOI: 10.1186/s10020-025-01085-w

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