Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.

doi:10.1038/s41591-021-01411-9

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Article

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.

Nature medicine - 1 Jul 2021

Saiki Ryunosuke, Momozawa Yukihide, Nannya Yasuhito, Nakagawa Masahiro M, Ochi Yotaro, Yoshizato Tetsuichi, Terao Chikashi, Kuroda Yutaka, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Niida Atsushi, Imoto Seiya, Matsuda Koichi, Morisaki Takayuki, Murakami Yoshinori, Kamatani Yoichiro, Matsuda Shuichi, Kubo Michiaki, Miyano Satoru, Makishima Hideki, Ogawa Seishi

Abstract excerpt

Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases. Previous studies of CH analyzed either single-nucleotide variants and indels (SNVs/indels) or copy number alterations (CNAs), but not both. Here, using a combination of targeted sequencing of 23 CH-related genes and array-based CNA detection of blood-derived...

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PMID: 34239136
DOI: 10.1038/s41591-021-01411-9

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