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Clinical relevance of clonal hematopoiesis and its interference in cell-free DNA profiling of patients with gastric cancer.

Clinical chemistry and laboratory medicine - 26 Jan 2024

Lee Kwang Seob, Lee Choong-Kun, Kwon Soon Sung, Kwon Woo Sun, Park Sejung, Lee Seung-Tae, Choi Jong Rak, Rha Sun Young, Shin Saeam

Abstract excerpt

OBJECTIVES: Clonal hematopoiesis (CH) is a condition in which healthy individuals have somatic mutations in hematopoietic stem cells. It has been reported with increased risk of hematologic malignancy and cardiovascular disease in the general population, but studies of Korean populations with comorbid disease entities are scarce. METHODS: White blood cells (WBCs) from patients with gastric cancer (GC) (n=121)...

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PMID: 37435889
DOI: 10.1515/cclm-2023-0261

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