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Article

Population-Based Identification of Clonal Hematopoiesis Using Peripheral Blood Whole-Genome Sequencing in Japan.

Cancer science - 1 Jul 2026

Chi SungGi, Motoike Ikuko N, Fujisawa Takao, Yamaguchi-Kabata Yumi, Nobukuni Takahiro, Kinoshita Kengo, Nakamura Yoshiaki, Bando Hideaki, Yoshino Takayuki, Ohneda Kinuko, Tsuchihara Katsuya, Minami Yosuke, Yamashita Riu

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-associated condition whose population-level characteristics and clinical concordance in Japan remain incompletely defined. We analyzed whole-genome sequencing data from 49,982 participants in the Tohoku Medical Megabank (TMM) cohort to characterize the prevalence, mutational spectrum, age dependency, and clinical relevance of CHIP. CHIP mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42053152
DOI: 10.1111/cas.70406
PMCID: PMC13327082

Genes

ASXL1
CBL
DNMT3A
GNAS
PPM1D
SMC3
TET2
ZNF318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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