Article
Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans.
Journal of virology - 1 Mar 2014
Mietzsch Mario, Broecker Felix, Reinhardt Anika, Seeberger Peter H, Heilbronn Regine
Abstract excerpt
All currently identified primary receptors of adeno-associated virus (AAV) are glycans. Depending on the AAV serotype, these carbohydrates range from heparan sulfate proteoglycans (HSPG), through glycans with terminal α2-3 or α2-6 sialic acids, to terminal galactose moieties. Receptor identification has largely relied on binding to natural compounds, defined glycan-presenting cell lines, or enzyme-mediated glycan...
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