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Article

The genomic architectures of tumour-adjacent tissues, plasma and saliva reveal evolutionary underpinnings of relapse in head and neck squamous cell carcinoma.

British journal of cancer - 1 Sept 2021

Wu Ping, Xie Chubo, Yang Ling, Liu Yalan, Zeng Junfeng, Li Xin, Fang Xing, Fan Yuhua, Zhao Suping, Kuang Ni, Xuan Tao, Xia Xuefeng, Yi Xin, Huang Yi, Yu Zicheng, Tang Yaoyun

Abstract excerpt

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is characterised by a dismal prognosis; nonetheless, limited studies have unveiled the mechanisms underlying HNSCC relapse. METHODS: Next-generation sequencing was performed to identify the somatic mutations in 188 matched samples, including primary tumours, tumour-adjacent tissues (TATs), pre- and post-operative plasma, saliva and peripheral blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34230611
DOI: 10.1038/s41416-021-01464-0
PMCID: PMC8438056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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