Deciphering molecular relapse and intra-tumor heterogeneity in non-metastatic resectable head and neck squamous cell carcinoma using circulating tumor DNA.

doi:10.1016/j.oraloncology.2024.107111

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Deciphering molecular relapse and intra-tumor heterogeneity in non-metastatic resectable head and neck squamous cell carcinoma using circulating tumor DNA.

Oral oncology - 1 Jan 2025

Marret Grégoire, Lamy Constance, Vacher Sophie, Cabel Luc, Séné Mathieu, Ahmanache Ladidi, Courtois Laura, El Beaino Zakhia, Klijanienko Jerzy, Martinat Charlotte, Servant Nicolas, Kamoun Choumouss, Halladjian Maral, Bronzini Thierry, Balsat Cédric, Laes Jean-François, Prévot Aubray, Sauvage Sébastien, Lienard Maxime, Martin Emmanuel, Genin Bérengère, Badois Nathalie, Lesnik Maria, Dubray-Vautrin Antoine, Choussy Olivier, Ghanem Wahib, Taouachi Rabah, Planchon Julien Masliah, Bièche Ivan, Le Tourneau Christophe, Kamal Maud

Abstract excerpt

OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genetic intra-tumor heterogeneity (ITH), which may hinder precision medicine strategies that depend on results from single tumor-biopsy specimens. Treatment response assessment relies on radiologic imaging, which cannot detect minimal residual disease (MRD). We assessed the relevance of circulating tumor DNA (ctDNA) as a...

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PMID: 39612700
DOI: 10.1016/j.oraloncology.2024.107111

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