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Longitudinal detection of somatic mutations in saliva and plasma for the surveillance of oral squamous cell carcinomas

3 Sept 2021

Abstract excerpt

PURPOSES: Although clinical and radiological examinations can be used to diagnose oral cancer, and surgical pathology remains the gold standard, these conventional methods have limitations. We evaluated the feasibility of longitudinal next-generation sequencing-based liquid biopsy for oral squamous cell carcinoma surveillance. MATERIALS AND METHODS: Eleven patients were enrolled, and plasma and saliva were...

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PMID: 34478472
DOI: 10.1371/journal.pone.0256979

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