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Article

NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.

Frontiers in immunology - 1 Jan 2022

Gong Xiao-Yang, Chen Hai-Bin, Zhang Li-Qing, Chen Dong-Sheng, Li Wang, Chen Dong-Hui, Xu Jin, Zhou Han, Zhao Le-le, Song Yun-Jie, Xiao Ming-Zhe, Deng Wang-Long, Qi Chuang, Wang Xue-Rong, Chen Xi

Abstract excerpt

Background: Patients with early-stage laryngeal cancer, even stage T1-2N0, are at considerable risk of recurrence and death. The genetic and immunologic characteristics of recurrent laryngeal cancer remain unclear. Methods: A total of 52 T1-2N0 laryngeal cancer patients were enrolled. Of these, 42 tissue samples were performed by targeted DNA sequencing, and 21 cases were performed by NanoString...

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Source

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Identifiers

PMID: 35911687
DOI: 10.3389/fimmu.2022.920253
PMCID: PMC9336464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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