Article

Brain tumor induce immunoregulatory dendritic cells in tumor draining lymph nodes that can be targeted by OX40

2024-04-02

Abstract excerpt

Brain tumors and metastases have a poor prognosis due to the unique characteristics of the central nervous system (CNS) and tumor immune microenvironment (TIME). CNS tumors exhibit limited infiltration and activation of dendritic cells (DCs) in tumor tissue and tumor-draining lymph nodes (TdLN), which regulate immune responses influenced by factors in the TIME. The immune response in the brain is significantly dif...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 846f6db7-a992-52b3-bfe5-6a0adfbbddb6
DOI: 10.1101/2024.04.01.587531

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brain tumor induce immunoregulatory dendritic cells in tumor draining lymph nodes that can be targeted by OX40DOI 10.1101/2024.04.01.587531Read

Conventional dendritic cells type I with an enhanced type-I-IFN signaling underpin anti-tumor immune responses in brain metastasesSemantic proximity Read

Tumors Located in the Brain Impair the Frequency and Phenotype of Dendritic Cells in Blood and TumorSemantic proximity Read

Exploiting tumor-associated dendritic cell heterogeneity for novel cancer therapiesSemantic proximity Read

Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical ImplicationsSemantic proximity Read

Phenotypic and functional differences of dendritic cells in tumor.Semantic proximity Read

CD137L dendritic cells induce potent response against cancer-associated viruses and polarize human CD8+ T cells to Tc1 phenotype.Semantic proximity Read

A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunitySemantic proximity Read

Phenotypes and Functions of Human Dendritic Cell Subsets in the Tumor Microenvironment.Semantic proximity Read

Tumor-associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance.Semantic proximity Read

Dendritic Cells in the Cancer MicroenvironmentSemantic proximity Read

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasisSemantic proximity Read

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastomaSemantic proximity Read