Article

<i>BIRC6</i> modifies risk of invasive bacterial infection in Kenyan children

2022-02-21

Abstract excerpt

Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibility loci for invasive infection that have been discovered to date are pathogen specific and are not therefore suggestive of a shared genetic architecture of bacterial s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7f1f35c-11e2-59b2-a8bf-7dfab744c805
DOI: 10.1101/2022.02.18.22271173

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>BIRC6</i> modifies risk of invasive bacterial infection in Kenyan childrenDOI 10.1101/2022.02.18.22271173Read

Genome admixture analysis of 1,030 Ugandan infants with neonatal sepsis and hydrocephalus demonstrates geographical stratification of population disease riskSemantic proximity Read

Rare variants in infection response protein pathways associated with sepsis in childrenSemantic proximity Read

Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan ChildrenSemantic proximity Read

Evidence for additive and interaction effects of host genotype and infection in malaria.Semantic proximity Read

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision.Semantic proximity Read

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.Semantic proximity Read

A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections.Semantic proximity Read

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precisionSemantic proximity Read

Discovery and validation of plasma-based protein biomarkers for the aetiological distinction of bacterial and non-bacterial febrile infections in African childrenSemantic proximity Read

Genome-wide association study of pediatric bacteremia and sepsisSemantic proximity Read

Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan childrenSemantic proximity Read

Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility.Semantic proximity Read