Article
Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.
eLife - 9 Jan 2017
Clarke Geraldine M, Rockett Kirk, Kivinen Katja, Hubbart Christina, Jeffreys Anna E, Rowlands Kate, Jallow Muminatou, Conway David J, Bojang Kalifa A, Pinder Margaret, Usen Stanley, Sisay-Joof Fatoumatta, Sirugo Giorgio, Toure Ousmane, Thera Mahamadou A, Konate Salimata, Sissoko Sibiry, Niangaly Amadou, Poudiougou Belco, Mangano Valentina D, Bougouma Edith C, Sirima Sodiomon B, Modiano David, Amenga-Etego Lucas N, Ghansah Anita, Koram Kwadwo A, Wilson Michael D, Enimil Anthony, Evans Jennifer, Amodu Olukemi K, Olaniyan Subulade, Apinjoh Tobias, Mugri Regina, Ndi Andre, Ndila Carolyne M, Uyoga Sophie, Macharia Alexander, Peshu Norbert, Williams Thomas N, Manjurano Alphaxard, Sepúlveda Nuno, Clark Taane G, Riley Eleanor, Drakeley Chris, Reyburn Hugh, Nyirongo Vysaul, Kachala David, Molyneux Malcolm, Dunstan Sarah J, Phu Nguyen Hoan, Quyen Nguyen Ngoc, Thai Cao Quang, Hien Tran Tinh, Manning Laurens, Laman Moses, Siba Peter, Karunajeewa Harin, Allen Steve, Allen Angela, Davis Timothy Me, Michon Pascal, Mueller Ivo, Molloy Síle F, Campino Susana, Kerasidou Angeliki, Cornelius Victoria J, Hart Lee, Shah Shivang S, Band Gavin, Spencer Chris Ca, Agbenyega Tsiri, Achidi Eric, Doumbo Ogobara K, Farrar Jeremy, Marsh Kevin, Taylor Terrie, Kwiatkowski Dominic P
Abstract excerpt
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report an analysis of...
Read the complete abstract on PubMed