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Article

A Comparison of Ex Vivo Expanded Human Regulatory T Cells Using Allogeneic Stimulated B Cells or Monocyte-Derived Dendritic Cells.

Frontiers in immunology - 1 Jan 2021

Lee Linda M, Zhang Hong, Lee Karim, Liang Horace, Merleev Alexander, Vincenti Flavio, Maverakis Emanual, Thomson Angus W, Tang Qizhi

Abstract excerpt

Alloreactive regulatory T cells (arTregs) are more potent than polyclonal Tregs at suppressing immune responses to transplant antigens. Human arTregs can be expanded with allogeneic CD40L-stimulated B cells (sBcs) or stimulated-matured monocyte-derived dendritic cells (sDCs). Here, we compared the expansion efficiency and properties of arTregs stimulated ex vivo using these two types of antigen-presenting cells....

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Identifiers

PMID: 34220826
DOI: 10.3389/fimmu.2021.679675
PMCID: PMC8253048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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