Article
Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.
Gut - 1 Apr 2016
Canavan James B, Scottà Cristiano, Vossenkämper Anna, Goldberg Rimma, Elder Matthew J, Shoval Irit, Marks Ellen, Stolarczyk Emilie, Lo Jonathan W, Powell Nick, Fazekasova Henrieta, Irving Peter M, Sanderson Jeremy D, Howard Jane K, Yagel Simcha, Afzali Behdad, MacDonald Thomas T, Hernandez-Fuentes Maria P, Shpigel Nahum Y, Lombardi Giovanna, Lord Graham M
Abstract excerpt
BACKGROUND AND AIM: Thymus-derived regulatory T cells (Tregs) mediate dominant peripheral tolerance and treat experimental colitis. Tregs can be expanded from patient blood and were safely used in recent phase 1 studies in graft versus host disease and type 1 diabetes. Treg cell therapy is also conceptually attractive for Crohn's disease (CD). However, barriers exist to this approach. The stability of Tregs...
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