Article
Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells.
Blood - 26 Sept 2013
Peters Jorieke H, Koenen Hans J P M, Fasse Esther, Tijssen Henk J, Ijzermans Jan N M, Groenen Patricia J T A, Schaap Nicolaas P M, Kwekkeboom Jaap, Joosten Irma
Abstract excerpt
Immunomodulating regulatory T-cell (Treg) therapy is a promising strategy in autoimmunity and transplantation. However, to achieve full clinical efficacy, better understanding of in vivo human Treg biology is warranted. Here, we demonstrate that in contrast to blood and bone marrow Tregs, which showed a resting phenotype, the majority of CD4(pos)CD25(pos)CD127(neg)FoxP3(pos) Tregs in secondary lymphoid organs...
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