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Article

The Yin and Yang of Type 1 Regulatory T Cells: From Discovery to Clinical Application.

Frontiers in immunology - 1 Jan 2021

Sayitoglu Ece Canan, Freeborn Robert Arthur, Roncarolo Maria Grazia

Abstract excerpt

Regulatory T cells are essential players of peripheral tolerance and suppression of inflammatory immune responses. Type 1 regulatory T (Tr1) cells are FoxP3- regulatory T cells induced in the periphery under tolerogenic conditions. Tr1 cells are identified as LAG3+CD49b+ mature CD4+ T cells that promote peripheral tolerance through secretion of IL-10 and TGF-β in addition to exerting perforin- and granzyme...

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Identifiers

PMID: 34177953
DOI: 10.3389/fimmu.2021.693105
PMCID: PMC8222711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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