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Article

Single-cell and multi-omic characterization of ex vivo expanded ASTRLs from stable kidney transplant recipients reveals a regulatory T cell phenotype.

Scientific reports - 14 Jan 2026

Tripathi Sudipta, Julé Amélie M, Zhuo Zhu, Schreiber Brittany L, Martin-Moreno Paloma L, Sui Shannan Ho, Waaga-Gasser Ana Maria, Chandraker Anil

Abstract excerpt

Therapeutic application of ex vivo expanded regulatory T cells is a promising approach to prolong allograft survival. In this work we performed a detailed characterization of a preclinical heterogenous antigen specific T enriched regulatory cell line (ASTRL) expanded ex vivo from PBMC of stable kidney transplant recipients. We used three different approaches: scRNA-seq, flow cytometry and mass cytometry, to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41535376
DOI: 10.1038/s41598-025-33656-6
PMCID: PMC12847790

Genes

CD4
CXCR6
DUSP10
IKZF4
IL2RA
TIGIT
TNFRSF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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