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Article

Cell Reprogramming to Model Huntington's Disease: A Comprehensive Review.

Cells - 22 Jun 2021

Monk Ruth, Connor Bronwen

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder characterized by the progressive decline of motor, cognitive, and psychiatric functions. HD results from an autosomal dominant mutation that causes a trinucleotide CAG repeat expansion and the production of mutant Huntingtin protein (mHTT). This results in the initial selective and progressive loss of medium spiny neurons (MSNs) in the striatum before...

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Identifiers

PMID: 34206228
DOI: 10.3390/cells10071565
PMCID: PMC8306243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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