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Article

Reversal of cellular phenotypes in neural cells derived from Huntington's disease monkey-induced pluripotent stem cells.

Stem cell reports - 14 Oct 2014

Carter Richard L, Chen Yiju, Kunkanjanawan Tanut, Xu Yan, Moran Sean P, Putkhao Kittiphong, Yang Jinjing, Huang Anderson H C, Parnpai Rangsun, Chan Anthony W S

Abstract excerpt

Huntington's disease (HD) is a dominant neurodegenerative disorder caused by the expansion of glutamine residues in the N-terminal region of the huntingtin (HTT) protein. The disease results in progressive neuronal loss, leading to motor, cognitive, and psychiatric impairment. Here, we report the establishment of neural progenitor cell (NPC) lines derived from induced pluripotent stem cells (iPSCs) of transgenic...

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Identifiers

PMID: 25358787
DOI: 10.1016/j.stemcr.2014.07.011
PMCID: PMC4223707

Genes

HTT

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