The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.

doi:10.3390/ijms22136760

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Article

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.

International journal of molecular sciences - 23 Jun 2021

Cresto Noémie, Gardier Camille, Gaillard Marie-Claude, Gubinelli Francesco, Roost Pauline, Molina Daniela, Josephine Charlène, Dufour Noëlle, Auregan Gwenaëlle, Guillermier Martine, Bernier Suéva, Jan Caroline, Gipchtein Pauline, Hantraye Philippe, Chartier-Harlin Marie-Christine, Bonvento Gilles, Van Camp Nadja, Taymans Jean-Marc, Cambon Karine, Liot Géraldine, Bemelmans Alexis-Pierre, Brouillet Emmanuel

Abstract excerpt

Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the C-terminal portion of LRRK2 (ΔLRRK2) with the G2019S mutation (ΔLRRK2G2019S) was sufficient to induce neurodegeneration of DA neurons in...

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PMID: 34201785
DOI: 10.3390/ijms22136760
PMCID: PMC8268201

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The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.PMID 34201785Read ↗

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