Article
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Neuron - 24 Dec 2009
Lin Xian, Parisiadou Loukia, Gu Xing-Long, Wang Lizhen, Shim Hoon, Sun Lixin, Xie Chengsong, Long Cai-Xia, Yang Wan-Jou, Ding Jinhui, Chen Zsu Zsu, Gallant Paul E, Tao-Cheng Jung-Hwa, Rudow Gay, Troncoso Juan C, Liu Zhihua, Li Zheng, Cai Huaibin
Abstract excerpt
Mutations in alpha-synuclein and Leucine-rich repeat kinase 2 (LRRK2) are linked to autosomal dominant forms of Parkinson's disease (PD). However, little is known about any potential pathophysiological interplay between these two PD-related genes. Here we show in transgenic mice that although overexpression of LRRK2 alone did not cause neurodegeneration, the presence of excess LRRK2 greatly accelerated the...
Topics
- Animals
- Brain
- Disease Progression
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Golgi Apparatus
- Inclusion Bodies
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice