Article

The C-terminal fragment of LRRK2 with the G2019S substitution increases the neurotoxicity of mutant A53T α-synuclein in dopaminergic neurons in vivo

2020-10-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) likely play crucial roles both in sporadic and familial forms of Parkinson’s disease (PD). The most prevalent mutation in LRRK2 is the G2019S substitution, which induces neurotoxicity through increased kinase activity. There is likely an interplay between LRRK2 and α-syn involved in the neurodegene...

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Literature Corpus work: 7b60a550-2973-5a9a-8a74-c649f1057084
DOI: 10.21203/rs.3.rs-24218/v2

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