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Article

G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Jul 2016

Volpicelli-Daley Laura A, Abdelmotilib Hisham, Liu Zhiyong, Stoyka Lindsay, Daher João Paulo Lima, Milnerwood Austen J, Unni Vivek K, Hirst Warren D, Yue Zhenyu, Zhao Hien T, Fraser Kyle, Kennedy Richard E, West Andrew B

Abstract excerpt

UNLABELLED: Pathologic inclusions define α-synucleinopathies that include Parkinson's disease (PD). The most common genetic cause of PD is the G2019S LRRK2 mutation that upregulates LRRK2 kinase activity. However, the interaction between α-synuclein, LRRK2, and the formation of α-synuclein inclusions remains unclear. Here, we show that G2019S-LRRK2 expression, in both cultured neurons and dopaminergic neurons in...

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Identifiers

PMID: 27413152
DOI: 10.1523/JNEUROSCI.3642-15.2016
PMCID: PMC4945663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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