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Article

α-Synuclein, Lrrk2 and Their Interplay In Parkinson‘s Disease

8 Mar 2012

Abstract excerpt

Of the various genetic factors contributing to the pathogenesis of Parkinson's disease (PD), only mutations in α-synuclein (α-syn) and LRRK2 genes cause clinical and neuropathological phenotypes closely resembling the sporadic cases. Therefore, studying the pathophysiological functions of these two PD-related genes is particularly informative in understanding the underlying molecular pathogenic mechanism of the...

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PMID: 22563296
DOI: 10.2217/fnl.12.2

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