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Joint metabolomics and transcriptomics analysis systematically reveal the impact of MYCN in neuroblastoma

30 Aug 2024

Abstract excerpt

The limited understanding of the molecular mechanism underlying MYCN-amplified (MNA) neuroblastoma (NB) has hindered the identification of effective therapeutic targets for MNA NB, contributing to its higher mortality rate compared to MYCN non-amplified (non-MNA) NB. Therefore, a comprehensive analysis integrating metabolomics and transcriptomics was conducted to systematically investigate the MNA NB....

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PMID: 39215128
DOI: 10.1038/s41598-024-71211-x

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