Article
Comprehensive genomic profiling of EWSR1/FUS::CREB translocation-associated tumors uncovers prognostically significant recurrent genetic alterations and methylation-transcriptional correlates.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2022
Dermawan Josephine K, Vanoli Fabio, Herviou Laurie, Sung Yun-Shao, Zhang Lei, Singer Samuel, Tap William D, Benayed Ryma, Bale Tejus A, Benhamida Jamal K, Dickson Brendan C, Antonescu Cristina R
Abstract excerpt
To elucidate the mechanisms underlying the divergent clinicopathologic spectrum of EWSR1/FUS::CREB translocation-associated tumors, we performed a comprehensive genomic analysis of fusion transcript variants, recurrent genetic alterations (mutations, copy number alterations), gene expression, and methylation profiles across a large cohort of tumor types. The distribution of the EWSR1/FUS fusion partners-ATF1,...
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