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Article

Modeling Extraordinary Response Through Targeting Secondary Alterations in Fusion-Associated Sarcoma.

JCO precision oncology - 1 Jun 2024

Vanoli Fabio, Song Evan, Dermawan Josephine K, Fishinevich Eve, Sung Patricia, Min Soe S, Xie Ziyu, de Traux de Wardin Henry, Hwang Sinchun, Maki Robert G, Antonescu Cristina R

Abstract excerpt

PURPOSE: Targeted therapy in translocation-associated sarcomas has been limited to oncogenic activation of tyrosine kinases or ligands while gene fusions resulting in aberrant expression of transcription factors have been notoriously difficult to target. Moreover, secondary genetic alterations in sarcomas driven by translocations are uncommon, comprising mostly alterations in tumor suppressor genes (TP53,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 38885476
DOI: 10.1200/PO.23.00688
PMCID: PMC11529323

Genes

BRAF
EWSR1
CDKN2A
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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