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Article

EWSR1‐CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma

20 Aug 2007

Abstract excerpt

The molecular hallmark of angiomatoid fibrous histiocytoma (AFH) is not well defined, with only six cases with specific gene fusions reported to date, consisting of either FUS-ATF1 or EWSR1-ATF1. To address this, we investigated the presence of FUS-ATF1, EWSR1-ATF1, and the highly related EWSR1-CREB1 fusion in a group of nine AFHs. All cases were subjected to RT-PCR for EWSR1-ATF1 and EWSR1-CREB1. FISH for EWSR1...

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PMID: 17724745
DOI: 10.1002/gcc.20491

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