NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

doi:10.1038/ng.3508

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Article

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

Nature genetics - 1 Apr 2016

Moriyama Takaya, Nishii Rina, Perez-Andreu Virginia, Yang Wenjian, Klussmann Federico Antillon, Zhao Xujie, Lin Ting-Nien, Hoshitsuki Keito, Nersting Jacob, Kihira Kentaro, Hofmann Ute, Komada Yoshihiro, Kato Motohiro, McCorkle Robert, Li Lie, Koh Katsuyoshi, Najera Cesar Rolando, Kham Shirley Kow-Yin, Isobe Tomoya, Chen Zhiwei, Chiew Edwynn Kean-Hui, Bhojwani Deepa, Jeffries Cynthia, Lu Yan, Schwab Matthias, Inaba Hiroto, Pui Ching-Hon, Relling Mary V, Manabe Atsushi, Hori Hiroki, Schmiegelow Kjeld, Yeoh Allen E J, Evans William E, Yang Jun J

Abstract excerpt

Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical determinant of thiopurine intolerance, but the underlying molecular mechanisms and the clinical implications of this pharmacogenetic association remain unknown. In...

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Identifiers

PMID: 26878724
DOI: 10.1038/ng.3508
PMCID: PMC5029084

Genes

NUDT15
TPMT

Variants

Provenance

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