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Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.

Inflammatory bowel diseases - 1 Sept 2017

Chao Kang, Wang Xueding, Cao Qian, Qian Jiaming, Wu Kaichun, Zhu Xia, Yang Hong, Liang Jie, Lin Lang, Huang Zicheng, Zhang Yu, Huang Yibiao, Sun Yinghao, Xue Xianmin, Huang Min, Hu Pinjin, Lan Ping, Gao Xiang

Abstract excerpt

BACKGROUND: NUDT15 c.415C>T was a novel genetic marker confirmed in our center for thiopurine-induced leukopenia in Chinese inflammatory bowel disease (IBD). For validation, a large cohort study is needed. Meanwhile, the newly discovered NUDT15 coding variants (c.36_37insGGAGTC and c.52 G>A) have not been studied in patients with IBD. We aimed to further confirm the influence of 3 NUDT15 variants (c.415C>T,...

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PMID: 28570428
DOI: 10.1097/MIB.0000000000001148

Genes

NUDT15

Variants

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Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.PMID 28570428Read ↗

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