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NUDT15 c.415C>T (rs116855232) Allele Frequency and Estimated Thiopurine Metabolizer Phenotype Distribution in the Iranian Population: A Study Based on Public Genomic Data

2026-08-21

Abstract excerpt

<title>Abstract</title> <p>Background Thiopurine drugs are widely used to treat acute lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD), both of which carry a substantial disease burden in Iran. NUDT15 is a major genetic determinant of thiopurine-induced myelosuppression, with allele frequencies known to vary widely across populations. Objectives Despite growing pharmacogenetic research in Iran,...

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Literature Corpus work
3aa894ab-7b70-524a-af75-9f2a38fdfcaf
DOI
10.21203/rs.3.rs-10636577/v1
Open publication

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NUDT15 c.415C&gt;T (rs116855232) Allele Frequency and Estimated Thiopurine Metabolizer Phenotype Distribution in the Iranian Population: A Study Based on Public Genomic DataDOI 10.21203/rs.3.rs-10636577/v1
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