Article
Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia.
Scientific reports - 10 Jan 2023
Yu Chih-Hsiang, Chang Ya-Hsuan, Wang Der-Shiun, Jou Shiann-Tarng, Lin Chien-Yu, Lin Kai-Hsin, Lu Meng-Yao, Wu Kang-Hsi, Cheng Chao-Neng, Chang Hsiu-Hao, Chou Shu-Wei, Su Min-Yu, Ni Yu-Ling, Xu Pei-Yuan, Lin Dong-Tsamn, Lin Shu-Wha, Chen Hsuan-Yu, Yang Yung-Li
Abstract excerpt
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in the Asian population. Two variants, c.55_56insGAGTCG in exon 1 and c.415C > T in exon 3, were commonly detected in the same allele, named NUDT15*1/*2. Although rare, compound...
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