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Article

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.

Blood - 7 Sept 2017

Moriyama Takaya, Yang Yung-Li, Nishii Rina, Ariffin Hany, Liu Chengcheng, Lin Ting-Nien, Yang Wenjian, Lin Dong-Tsamn, Yu Chih-Hsiang, Kham Shirley, Pui Ching-Hon, Evans William E, Jeha Sima, Relling Mary V, Yeoh Allen Eng-Juh, Yang Jun J

Abstract excerpt

Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose-limiting hematopoietic toxicities, which is partly explained by inherited genetic polymorphisms in drug metabolizing enzymes (eg, TPMT). Recently, our group and others identified germ line genetic variants in NUDT15 as another major cause of...

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Source

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Identifiers

PMID: 28659275
DOI: 10.1182/blood-2017-05-782383
PMCID: PMC5606007

Genes

NUDT15
TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.PMID 28659275Read ↗

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Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.Semantic proximity Read ↗

Emerging role of NUDT15 polymorphisms in 6-mercaptopurine metabolism and dose related toxicity in acute lymphoblastic leukaemia.Semantic proximity Read ↗

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.Semantic proximity Read ↗

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