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Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.

Biological & pharmaceutical bulletin - 1 Jan 2023

Isono Tetsuichiro, Hira Daiki, Ikeda Yoshito, Kawahara Masahiro, Noda Satoshi, Nishida Atsushi, Inatomi Osamu, Fujimoto Noriki, Andoh Akira, Terada Tomohiro, Morita Shin-Ya

Abstract excerpt

While nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene polymorphism Arg139Cys (rs116855232) is known to be a risk factor for thiopurine-induced severe leukopenia, association with the NUDT15 gene polymorphism Arg139His (rs147390019) has not yet been clarified. In addition, the accuracy of TaqMan PCR to assess these two polymorphisms has not been investigated. In this study, we evaluated TaqMan...

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PMID: 36858569
DOI: 10.1248/bpb.b22-00686

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Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.PMID 36858569Read ↗

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.Semantic proximity Read ↗

NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review.Semantic proximity Read ↗

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.Semantic proximity Read ↗

Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis.Semantic proximity Read ↗

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.Semantic proximity Read ↗

Association of NUDT15 c.415C>T allele and thiopurine-induced leukocytopenia in Asians: a systematic review and meta-analysis.Semantic proximity Read ↗

Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.Semantic proximity Read ↗

A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T.Semantic proximity Read ↗

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Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose.Semantic proximity Read ↗

NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease.Semantic proximity Read ↗

NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases.Semantic proximity Read ↗

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