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Article

Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Aug 2021

Pan Gang, Cavalli Marco, Wadelius Claes

Abstract excerpt

The stearoyl-CoA desaturase 1 (SCD1) gene at 10q24.31 encodes the rate limiting enzyme SCD1 that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids (SFAs). Dysregulated SCD1 activity has been observed in many human diseases including non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and several types of cancer. HNF4A is a...

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PMID: 34171462
DOI: 10.1016/j.bbagrm.2021.194724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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