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A Single Nucleotide Polymorphism (rs3811792) Affecting Human SCD5 Promoter Activity Is Associated with Diabetes Mellitus.

Genes - 3 Oct 2022

Zámbó Veronika, Orosz Gabriella, Szabó Luca, Tibori Kinga, Sipeki Szabolcs, Molnár Krisztina, Csala Miklós, Kereszturi Éva

Abstract excerpt

The combined prevalence of type 1 (T1DM) and type 2 (T2DM) diabetes mellitus is 10.5% worldwide and this is constantly increasing. The pathophysiology of the diseases include disturbances of the lipid metabolism, in which acyl-CoA desaturases play a central role as they synthesize unsaturated fatty acids, thereby providing protection against lipotoxicity. The stearoyl-CoA desaturase-5 (SCD5) isoform has received...

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Identifiers

PMID: 36292669
DOI: 10.3390/genes13101784
PMCID: PMC9601412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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