Article
Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation.
Molecular genetics and metabolism - 1 Mar 2012
Stryjecki Carolina, Roke Kaitlin, Clarke Shannon, Nielsen Daiva, Badawi Alaa, El-Sohemy Ahmed, Ma David W L, Mutch David M
Abstract excerpt
Fatty acids (FA) represent a diverse class of molecules known to regulate inflammatory pathways. Therefore enzymes that regulate FA metabolism are attractive candidates to better understand the relationship between FA and inflammation. Stearoyl-CoA desaturase 1 (SCD1) is rate limiting for the conversion of saturated FA (SFA) to monounsaturated FA (MUFA). Evidence suggests that SCD1 activity may be positively...
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