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Article

A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia.

Journal of clinical lipidology - 1 Jan 2000

de Toro-Martín Juan, Guénard Frédéric, Rudkowska Iwona, Lemieux Simone, Couture Patrick, Vohl Marie-Claude

Abstract excerpt

BACKGROUND: Numbers of single nucleotide polymorphisms (SNPs) associated with fatty acid desaturase activities have been previously identified within the FADS1-FADS2 gene cluster, which encodes delta-5 (D5D) and delta-6 (D6D) desaturases, respectively. OBJECTIVE: We aimed at further characterizing the genetic variability associated with D5D and D6D activities on a genome-wide scale. METHODS: We conducted a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29246731
DOI: 10.1016/j.jacl.2017.10.020

Genes

ARHGEF10
FADS1
FADS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia.PMID 29246731Read ↗

Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.Semantic proximity Read ↗

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FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.Semantic proximity Read ↗

FADS2 Variants are Associated with Omega-6 Metabolic Conversion in Serbian Adults in a cross-sectional study – Implications for Precision Nutrition PracticeSemantic proximity Read ↗

Recent insights into the relation of Δ5 desaturase and Δ6 desaturase activity to the development of type 2 diabetes.Semantic proximity Read ↗

Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults.Semantic proximity Read ↗

Influence of Fatty Acid Desaturase Enzyme-1 Gene (FADS-1) Polymorphism on Serum Polyunsaturated Fatty Acids Levels, Desaturase Enzymes, Lipid Profile, and Glycemic Control Parameters in Newly Diagnosed Diabetic Mellitus PatientsSemantic proximity Read ↗

Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements.Semantic proximity Read ↗

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