Article
Early infiltrating macrophage subtype correlates with late-stage phenotypic outcome in a mouse model of hepatorenal fibrocystic disease.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2021
Zimmerman Kurt A, Song Cheng J, Aloria Ernald J G, Li Zhang, Zhou Juling, Bland Sarah J, Yashchenko Alex, Crossman David K, Mrug Michal, Yoder Bradley K
Abstract excerpt
Hepatorenal fibrocystic disease (HRFCD) is a genetically inherited disorder related to primary cilia dysfunction in which patients display varying levels of fibrosis, bile duct expansion, and inflammation. In mouse models of HRFCD, the phenotype is greatly impacted by the genetic background in which the mutation is placed. Macrophages are a common factor associated with progression of HRFCD and are also strongly...
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