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Transcriptional profiling of pediatric cholestatic livers identifies three distinct macrophage populations

7 Jan 2021

Abstract excerpt

BACKGROUND & AIMS: Limited understanding of the role for specific macrophage subsets in the pathogenesis of cholestatic liver injury is a barrier to advancing medical therapy. Macrophages have previously been implicated in both the mal-adaptive and protective responses in obstructive cholestasis. Recently two macrophage subsets were identified in non-diseased human liver; however, no studies to date fully define...

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PMID: 33411796
DOI: 10.1371/journal.pone.0244743

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