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Macrophage heterogeneity in liver injury and fibrosis

8 Jan 2014

Abstract excerpt

Hepatic macrophages are central in the pathogenesis of chronic liver injury and have been proposed as potential targets in combatting fibrosis. Recent experimental studies in animal models revealed that hepatic macrophages are a remarkably heterogeneous population of immune cells that fulfill diverse functions in homeostasis, disease progression, and regression from injury. These range from clearance of pathogens...

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Identifiers

PMID: 24412603
DOI: 10.1016/j.jhep.2013.12.025

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